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Description:
Author(s):
Gunasekera, S. P., Miller, M. W., Kwan, J. C., Luesch, H., Paul, V. J.
Title:
Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis
Publication Date:
2010
Journal Title:
Journal of Natural Products
Volume:
73
Issue:
3
Page(s):
459-462
Abstract:
"A new dolastatin 13 analogue, molassamide (1), was isolated from cyanobacterial assemblages of Dichothrix utahensis collected from the Molasses Reef, Key Largo, Florida, and from Brewers Bay, St. Thomas, U.S. Virgin Islands. This is the first peptide reported from the cyanobacterial genus Dichothrix and the first natural product isolated from marine Dichothrix spp. Its planar structure was determined by NMR spectroscopic techniques, and the configurations of the asymmetric centers were assigned after chiral HPLC analysis of the hydrolysis products. The depsipeptide 1 exhibited protease-inhibitory activity, with IC50 values of 0.032 and 0.234 uM against elastase and chymotrypsin, respectively. There was no apparent inhibition of trypsin at 10 uM, the highest concentration tested."
Electronic DOI:
Notes:
CRCP Project ID 1066; Project Title: Ecological Approach to Coral Reef Restoration; Principal Investigator: Margaret Miller
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